Revolutionizing Genetic Kinship Analysis

In 1865, Mendel established the fundamental rule of genetic inheritance. According to Mendel’s Law of Segregation, individuals possess two sets of genes, with each parent passing only one set to their offspring. Consequently, KinTouch Plus 4 share half of our genes with our mother and half with our father, and genetic relatedness decreases by half with each increasingly distant branch in our family tree, as shown in the table below.

In line with Mendel’s law, the KinTouch Paternity+4 Test employs crossover genomic hybridization to determine the genetic relatedness between two individuals by comparing the DNA sequence in the context of >3 million SNPs of human genome. In theory, the sequence similarity for 1st and 2nd-degree kinship can be correlated to 50% and a 25% genomic sequence similarity, respectively, providing a simple and accurate means to assess genetic relatedness by KinTouch touch DNA test.

Distinctive Features

Beyond STR Markers:

Discover the advantages of our genome-wide SNP methodolog

Unlike STRs, SNPs are more stable genetic markers, with low mutation rates (approximately 10−8), making them less likely to undergo changes over generations—a crucial factor in paternity cases. An unpredictable mutation often leads to the STR paternity test result incompatible with Mendel's law of inheritance. Consequently, an STR-based paternity test bears a false-negative rate 100 times higher than the false-positive rate, resulting in over 2% of uncertain test results.

In fact, a typical STR paternity indices (PIs) is 103–104 for the child–father duos and 105–106 for the mother–child–father trios, consistently less than 100%. In contrast, genome-wide SNP DNA testing can achieve a diagnostic accuracy of 100%, providing certainty, and is particularly useful for distinguishing one genetic lineage from another.

Comprehensive Kinship Analysis:

Learn how our whole genome crossover hybridization provides a thorough kinship analysis.

According to Mendel’s Law of Segregation, individuals possess two sets of genes, with each parent passing only one set to their offspring. Consequently, we share half of our genes with our mother and half with our father, and genetic relatedness decreases by half with each increasingly distant branch in our family tree, establishing the fundamental rule of genetic relatedness without a priori assumptions.

The KinTouch Paternity+4 Test employs Mendel’s law of segregation to determine the genetic distance between test subjects. Genetic distance is assessed by comparing DNA sequence similarity through whole-genome crossover hybridization, considering 3 million single nucleotide polymorphisms (SNPs) naturally occurring among all human genomes. A 50% and a 25% DNA sequence similarity directly correlate with 1st and 2nd-degree genetic relatedness, respectively, providing a comprehensive assessment of kinship, including paternity, siblings, half-siblings, grandparents/grandchildren, and aunts/uncles/nephews/nieces.